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Prices, terms, promotions, features, options, amenities, floor plans, elevations, designs, materials, square footages, associations fees, and descriptions are subject to change without notice. Prices shown refer to the base house and do not include any optional features, upgrades, lot premiums, upgrade exterior elevations, or association fees. Square footages are approximate and may vary in construction and depending on the standard measurement used. KB Home reserves the right to make changes to its home designs and to build more or fewer homes than currently planned. Any energy savings, community or neighborhood benefits, features, descriptions, views, open spaces, conservation areas, golf courses, and school information are not guaranteed, are subject to change or modification at any time, and certain items may require a separate membership fee and/or fee for use. Individual energy costs and savings will vary. Any estimated energy costs or savings should not be relied upon in any way when making purchasing decisions. KB Home does not guarantee that any specific level of energy utility costs or savings will be achieved or maintained, even if the home is built as designed per the relevant home plan. Actual energy utility costs or savings will depend on a number of factors, including but not limited to daily activities, home maintenance practices, household size, use of appliances, lighting and internal climate control systems, and the surrounding climate and weather conditions.

All renderings and floor plans are an artists' conceptual drawings and will vary from the actual plans and homes as built. Home images, colors and sizes are approximate for illustration purposes only and may not represent the lowest-priced homes in the community. Images show model homes displaying options/upgrades and upgraded landscaping which may be available at predetermined stages of construction for additional charges. If construction cut-off deadlines have passed, certain options/upgrades may no longer be available. Models also display many decorator items and furniture which are not available for purchase even upon additional payment. Visit the community for detailed lists of options/upgrades and decorator items and for additional important disclosures for the community and the home. Images do not reflect any racial preference. Maps may not be to scale. This is not an offering to residents of NY, NJ or CT or where otherwise prohibited by law. Equal Housing Opportunity.

KB Home Sales – Southern California Inc. (Real Estate License #00242327)

Many features/upgrades preselected and included at no additional cost. Buyer may be required to pay for any additional features/upgrades and is responsible for all taxes, insurance and other fees. Plans, inventory pricing, financing, terms, availability and specifications subject to change without notice and may vary by neighborhood, homesite location and home series. Square footage is approximate. Not all plans ready for immediate move-in. Quick move-in homes may require up to a certain number of days/months before availability for closing. See sales agent for approximate timing required for quick move-in homes. Photos show upgraded landscaping and may not represent standing inventory as listed.

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Residence Three
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Residence Three
Priced from $256,990 – $293,990

break me off a piece of that. 📸 | styling: @scoutallen @misschls

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(@mallowmallow) 分享的帖子 ·

Location: Food South

Mallow Mallow brings classic campfire s’mores fresh to you, but with none of the hassle. Try out their festival-exclusive unicorn frozen hot chocolate one.

Spring forward with our glorious #MacAndCheesePizza and homemade #BloodyMary! Every Sunday 11 AM - 10 PM in #LBC #DTLA! Classic 5-cheese blend or vegan! By the slice or whole pie! Dine in, pick up or delivery! Place your order online at www.pizzanista.com #GetSome ✌🏼❤️🍕🧀

PIZZANISTA! (@pizzanista) 分享的帖子 ·

Location: Craft Beer Barn

Mac-and-cheese pizza. That is all that needs to be said.

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milk bar (@milkbarstore) 分享的帖子 ·

Milk Bar is the brainchild of celebrated pastry chef Christina Tosi, and it’s filled with imaginative cookies, cakes and pies. But if for nothing else, Milk Bar is known for its Cereal Milk™ Soft Serve – and let me tell you: it’s amazing. It will have you reminiscing over the good ol’ days. You must must get the ice cream with the cornflake crunch topping. It brings it to a whole ’nother level.

If millennial pink ice cream shops aren't your scene, Little Damage has got your dark soul covered with their Insta-famous charcoal soft serve. Get on it.

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Sweetfin (@sweetfin) 分享的帖子 ·

Location: Indio Central Market VIP (near white peak tents)

BØRNS, performing Saturday, teamed up with Sweetfin to create a Coachella exclusive poke bowl. The "Blue Madonna" bowl, is inspired by the Indie artist’s latest album by the same name. How meta would it be to eat the "Blue Madonna" bowl… while listening to "Blue Madonna?"

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GT's Kombucha (@gtskombucha) 分享的帖子 ·

Location: Indio Central Market VIP (near the white peak tents)

This. Is. Not. A. Drill. GT’s is serving KOMBUCHA POPSICLES so you can stay cool and get your daily dose of gut-friendly probiotics. Does it get any more California than this?

The Refugee Family Mentoring and Resource Program involves ‘mentors’ from Assyrian/Chaldean, Karen/Burmese and South Sudanese backgrounds working directly with families to support their access to early childhood services including MCH services, kindergartens, early intervention and family welfare services [ Robert Rodriguez Suede KneeLength Dress 2018 New Sale Online Good Selling Cheap Price Outlet 100% Original With Paypal Free Shipping Low Shipping Cheap Price VIgsG72OA
]. This model supports families through organised playgroups [ Drop Shipping Original For Sale 31 Phillip Lim Merino Wool Sweater Dress VhXFXEZARe
] and operates differently for each cultural group to meet the needs and circumstances of the playgroup participants.

At two Karen playgroups the refugee mentor was effective in introducing parents who arrive with pre-school aged children to the MCH service. The refugee mentor’s role involves organising mothers and children to attend their ‘key ages and stages’ visits and working closely with the MCH nurse to ensure mothers are seen in this group setting. This model is working so well that parents are ‘referred’, usually by healthcare providers, to the playgroup rather than to the MCH service itself.

It was evident that the model at the Karen playgroups enhanced access to the MCH service for this group of people and likely that the group setting provided an opportunity for culturally supportive discussions about child health and development. However, consideration must also be given to ensuring that women have access to individual appointments, with an interpreter, where they may feel less constrained about discussing issues of concern with the MCH nurse. When the bilingual community workers and the managers were asked if the women attending group sessions would be receiving the same level of care as an English-speaking mother with an individual appointment it was reported that they would be getting the same level of care because of the skills of the MCH nurse in being alert to broader issues:

Several participants from Iraqi and Assyrian Chaldean backgrounds were not linked to a refugee mentor and had not heard of the MCH service. One Iraqi participant had heard about the service from her husband who had arrived in Australia prior to her.

Many participants across all cultural groups described how important the service was for them. The concepts of preventive health, well-child checks and early detection of child development delays were new for all participants. One participant explained the value of the MCH service for her and her community:
The ‘refugee mentor’ model functioned differently for the Assyrian Chaldean community. The women in this group had been in the country longer and could understand basic spoken English but were not confident in speaking it. The refugee mentor encouraged mothers to make their own appointments at the MCH centre. This was working well for some although several had not heard of the service before. Several Iraqi mothers reported that they didn’t realise until they used the service that the nurse also checked the mother’s physical and emotional health, they described this as a new concept and felt it was important to them.
Again, the ‘refugee mentor’ model worked differently for the South Sudanese mothers. This group had not identified having the MCH nurse visit their playgroup as a priority. Although there were some mothers with children born in Melbourne who were using the service, others had used it previously but had encountered significant barriers for continued utilisation of the service. One mother reported that she had walked to a MCH centre with her children and was given a phone number and told to return home and call to make an appointment. Another mother had a new baby and was told that her preferred centre, where she already took her other children, was too busy and that she would have to go to another one which was further away from her home and difficult for her to walk to with her multiple children. She did not want to question the direction to attend another centre because she didn’t want to appear as though she did not care about her children.

Several MCH nurses reported that it was often difficult for them to call parents to remind them that they were due for an appointment aligned with the ‘key ages and stages’ visits while also trying to explain that the service is free and completely voluntary. Some mothers reported that they would like to see the nurses more often than the 10 ‘key ages and stages’ with the gap between 2 and 3.5 years in particular, considered too long. Most parents were unaware that they could access the MCH service for individual consultations even if it was outside of the ‘key ages and stages’ visits. However, the MCH nurses in one area reported that although they would welcome people approaching them, they did not actively encourage it, as they were extremely busy and felt they did not have the capacity for additional appointments. When mothers were asked where they would seek information on their child’s health and development, should they ever need it, responses included: family, friends and their General Practitioner (GP), rarely was the MCH nurse viewed as a source of information.

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La estructura de la telomerasa , una enzima clave en el envejecimiento y el cáncer , ha dejado de ser un misterio. La ha descifrado una investigación de la Universidad de California en Berkeley (Estados Unidos), publicada esta semana en la revista Nature . El avance abre la vía a diseñar nuevas terapias contra el cáncer basadas en su estructura molecular.

El mecanismo de replicación del ADN no permite duplicar bien los extremos de los cromosomas cuando las células se dividen, por lo que cada vez se hacen un poco más cortos. En teoría, con cada división de las células, se perdería información genética. Pero eso no ocurre gracias a los telómeros, que protegen los extremos de los cromosomas, como si fueran las puntas de plástico que protegen los cordones de los zapatos. La enzima telomerasa es la encargada de mantener los telómeros íntegros, alargándolos para compensar el acortamiento en cada división.

Cuando los telómeros se encogen demasiado, las células frenan su división y entran en un estado llamado de senescencia, relacionado con el envejecimiento. Pero si la telomerasa está demasiado activa y no deja de alargar los telómeros, se puede producir una multiplicación descontrolada de las células, como un coche en bajada sin frenos, que puede derivar en un cáncer.

Aunque la telomerasa se descubrió hace más de veinte años, su estructura ha eludido los esfuerzos de los científicos hasta ahora. Para desvelarla, los investigadores de la Universidad de Berkeley han utilizado una técnica llamada criomicroscopía electrónica, que permite ver moléculas a gran resolución y que el año pasado ganó el Nobel de Química.

Las imágenes que han obtenido, de una resolución menor que una millonésima parte de un milímetro, han revelado una estructura altamente compleja, formada por proteínas y ácidos ribonucleicos (ARN). Conocerla permitirá diseñar fármacos que se unan a ella como tratamiento contra el cáncer.

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